The Highlander has a standard Secondary Collision Brake, which automatically applies the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The Outlander doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.
The Toyota Highlander’s rear backup camera has a standard washer for maintaining a clear view under various conditions. In contrast, the Mitsubishi Outlander does not offer a rear camera washer, meaning its effectiveness relies on manual cleaning by the user when necessary.
Both the Highlander and Outlander have Rear Cross Traffic Alert, but the Highlander Limited/Platinum has Parking Support Brake (automatically applies the brakes) to better prevent a collision when backing near traffic. The Outlander’s Rear Cross Traffic Alert doesn’t automatically brake.
Both the Highlander and the Outlander have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, front wheel drive, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, blind spot warning systems, rearview cameras, rear cross-path warning, driver alert monitors, available all wheel drive and around view monitors.
Side impacts caused 23% of all road fatalities in 2018, down from 29% in 2003, when the Insurance Institute for Highway Safety introduced its side barrier test. In order to continue improving vehicle safety, the IIHS has started using a more severe side impact test: 37 MPH (up from 31 MPH), with a 4180-pound barrier (up from 3300 pounds). The results of this newly developed test demonstrates that the Toyota Highlander is safer than the Outlander:
| 
 | Highlander | Outlander | 
| Overall Evaluation | GOOD | GOOD | 
| Structure | GOOD | ACCEPTABLE | 
| 
 | Driver Injury Measures | |
| Head/Neck | GOOD | GOOD | 
| Head Injury Criterion | 71 | 171 | 
| Neck Tension | 156 lbs. | 201 lbs. | 
| Torso | GOOD | ACCEPTABLE | 
| Shoulder Deflection | .51 in | .71 in | 
| Torso Max Deflection | 1.26 in | 1.46 in | 
| Torso Deflection Rate | 6 MPH | 8 MPH | 
| Head Protection | GOOD | GOOD | 
| 
 | Passenger Injury Measures | |
| Head/Neck | GOOD | GOOD | 
| Torso | GOOD | GOOD | 
| Pelvis | GOOD | GOOD | 
| Pelvis Force | 201 lbs. | 647 lbs. | 
| Head Protection | GOOD | GOOD | 
Instrumented handling tests conducted by the National Highway Traffic Safety Administration and analysis of its dimensions indicate that the Highlander is 1% to 3.4% less likely to roll over than the Outlander.

